Latest Herpes Cure Update

The post Latest Herpes Cure Update appeared first on Meet Positives.

The ongoing study for the cure of Herpes Virus

The herpesvirus is mostly present in adults. Just like AIDS and cancer, there is no known cure to herpes infections. It is a lifelong disease, and once contracted the virus will stay in your cell for life.

Being conscious with your lifestyle is important and practicing an acceptable norms with regards to dating and relationship will likely help in avoiding this irritating, lifetime disease. As we know, the herpes virus is commonly spreads by means of sexual contact. It’s no wonder why most adults get infected by herpes simplex.

An ongoing study about herpesvirus has long been started up to this day. The most recent is the study made with CRISPR/Cas9 targeting the infection. The article below is packed of the latest information about the cure towards herpesviruses.


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Most adults carry multiple herpesviruses. Following the initial acute infection, these viruses establish life-long infections in their hosts and cause cold sores, keratitis, genital herpes, shingles, infectious mononucleosis, and other diseases. Some herpesviruses can cause cancer in man. During the latent phase of infection, the viruses remain dormant for long periods of time, but retain the capacity to cause occasional reactivations, that may lead to disease. A study published on June 30th in PLOS Pathogens suggests that attacking herpesvirus DNA with CRISPR/Cas9 genome editing technology can suppress virus replication and, in some cases, lead to elimination of the virus.

The CRISPR/Cas9 system targets specific DNA sequences and induces clean cuts across both strands of the DNA. In mammalian cells, such cuts are flagged and quickly repaired by an emergency repair system called NHEJ (for non-homologous end-joining). NHEJ is efficient but not very accurate and often results in insertion or deletion of a few DNA bases at the repair site. Because DNA is read in codons of three bases at a time, such small changes in critical positions often destroy the function of the respective gene and its protein product.

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Robert Jan Lebbink, from the University Medical Center in Utrecht, The Netherlands, and colleagues reasoned that CRISPR/Cas9 could target and mutate latent herpesvirus DNA in infected human cells and so potentially prevent herpesvirus-associated diseases. To test this, the researchers devised specific guide (g)RNAs–sequences that are complementary to vital parts of the viral genome and function as ‘molecular addresses’. These gRNAs, combined with the ‘molecular scissors’ part of the CRISPR/Cas9 system, should induce specific cuts and subsequent mutations in the herpesvirus DNA, and so cripple the viruses.

In their systematic approach, the researchers looked at three different members of the herpesvirus group: herpes simplex virus type 1 (HSV-1) causing cold sores and herpes keratitis; human cytomegalovirus (HCMV), the most common viral cause of birth defects (when the virus is transmitted from mother to fetus); and Epstein-Barr virus (EBV) causing infectious mononucleosis and multiple types of cancer.

Working with lymphoma cells latently infected with EBV, the researchers showed that introduction of gRNAs that target specific EBV DNA sequences can introduce mutations at the targeted sites. Such mutations can eliminate essential functions of the virus as well as destabilize the viral DNA molecules. Consistent with this, the researchers report that by using two different gRNAs targeting an essential EBV gene, they can induce loss of over 95% of EBV genomes from the host cells.

During latent infection, HCMV genomes exist as circular DNA molecules in the nucleus of host cells. Upon virus reactivation, HCMV replication proceeds slowly. With appropriate gRNAs, the researchers found that CRISPR/Cas9 editing can efficiently impair HCMV replication. However, they also observed emergence of escape variants that bypass CRISPR/Cas9 editing, suggesting that simultaneous editing at multiple critical sites in the HCMV genome is necessary to avoid the development of resistant genomes.

Compared to HCMV, HSV-1 multiplies much faster. When the researchers tested various gRNAs targeting different essential HSV-1 genes in conjunction with CRISPR/Cas9, they found that many of them were able to reduce virus replication. When they combined two of those gRNAs, thereby simultaneously targeting two essential genes, they were able to completely suppress HSV-1 replication. On the other hand, they were unable to induce editing during the latent phase, i.e. when the viral DNA was not actively multiplying.

“We observed highly efficient and specific clearance of EBV from latently infected tumor cells and impairment of HSV-1 and HCMV replication in human cells,” the researchers summarize. They go on to say, “although CRISPR/Cas9 was inefficient at directing genome engineering of quiescent HSV-1, virus replication upon reactivation of quiescent HSV-1 was efficiently abrogated using anti-HSV-1 gRNAs.” Their results, they hope, “may allow the design of effective therapeutic strategies to target human herpesviruses during both latent and productive infections.”

The study is a good news for everyone with herpes simplex because this means the cure is almost achievable. Maybe the cure will not be available for the coming years but knowing that there is a progress is truly a relief for people with herpes infection.

For now, if you have herpes and looking for love, join our website!

 

 

Did you Know? 19.7 Million New STIs Cases every year in U.S

The post Did you Know? 19.7 Million New STIs Cases every year in U.S appeared first on Meet Positives.

Statistic Shows that 19.7 million new STIs are recorded every year in the U.S

Many cases of notifiable STI are undiscovered and some common viral infections are not reported. STI are usually spread by having oral, vaginal or anal sex. The recent data from Centers for Disease Control and Infection show that there are 19.7 million new STI’s every year in the U.S and women often have more serious health problems than men including infertility.

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19.7 million new STIs are recorded every year in the U.S

  • – More than half of all people will have an STD/STI at some point in their lifetime.
  • – Recent estimates from the Centers for Disease Control and Infection show that there are 19.7 million new STIs every year in the U.S.
  • – In 2008, there were an estimated 110 million prevalent STIs among women and men in the U.S.. Of these, more than 20% (22.1 million) were among women and men aged 15 to 24 years.
  • – The total estimated direct cost of STIs annually in the U.S. is $15.6 billion (2010 US dollars).
  • – In a national survey of US physicians, fewer than one-third routinely screened patients for STDs/STIs.
  • – Each year, one in four teens contracts an STD/STI.
  • – One in two sexually active persons will contract an STD/STI by age 25.
  • – About half of all new STDs/STIs in 2000 occurred among youth ages 15 to 24. The total estimated costs of these nine million new cases of these STDs/STIs was $6.5 billion, with HIV and human papillomavirus (HPV) accounting for 90% of the total burden.
  • – Of the STDs/STIs that are diagnosed, only some (gonorrhea, syphilis, chlamydia, hepatitis A and B) are required to be reported to state health departments and the CDC.
  • – One out of 20 people in the United States will get infected with hepatitis B (HBV) some time during their lives. Hepatitis B is 100 times more infectious than HIV.
  • – Approximately half of HBV infections are transmitted sexually.HBV is linked to chronic liver disease, including cirrhosis and liver cancer.
  • – It is estimated that as many as one in five Americans have genital herpes, a lifelong (but manageable) infection, yet up to 90 percent of those with herpes are unaware they have it.
  • – With more than 50 million adults in the US with genital herpes and up to 776,000 new infections each year, some estimates suggest that by 2025 up to 40% of all men and half of all women could be infected.
  • – Over 14 million people acquire HPV each year,and by age 50, at least 80 percent of women will have acquired genital HPV infection. Most people with HPV do not develop symptoms.
  • – Each year, there are almost 3 million new cases of chlamydia, many of which are in adolescents and young adults.
  • – About two-thirds of young females believe doctors routinely screen teens for chlamydia.However, in 2003 only 30% of women 25 and under with commercial health care plans and 45% in Medicaid plans were screened for chlamydia.
  • – At least 15 percent of all American women who are infertile can attribute it to tubal damage caused by pelvic inflammatory disease (PID), the result of an untreated STD. Consistent condom use reduces the risk of recurrent PID and related complications: significantly, women who reported regular use of condoms in one study were 60 percent less likely to become infertile.
  • – Consistent condom use provides substantial protection against the acquisition of many STDs, including statistically significant reduction of risk against HIV, chlamydia, gonorrhea, herpes, and syphilis.

With the growing number of cases of STD/ STI in the United States, everyone should merely understand what are the symptoms and treatments that can help every individual prevent the spread of the disease. Programs and consultation is the best option to have yourself check and talk to professionals about STIs. How to prevent them and basically how you can get treated with this infection.

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Sexually transmissible infections (STIs) are common all around the world. They may be caused by bacteria, viruses or parasites. You may think that only other people get STIs and that you are not at risk of catching one, but anybody who is sexually active can get an STI if they do not practice safe sex.

You can’t tell just by looking at a person that they have an STI. If you have unprotected sex with a person who has an STI, you are at high risk of catching that infection.

Sexually transmissible infections include chlamydia, herpes, gonorrhoea, syphilis, genital herpes, scabies, pubic lice (crabs), hepatitis and HIV (the virus that causes AIDS).

If you think you have been exposed to an STI, it’s a good idea to talk to your doctor or sexual health service about having a check-up, even if you do not have any signs or symptoms of an STI. Don’t try to diagnose your symptoms yourself, and remember that not all genital signs and symptoms are caused by an STI.

Symptoms of STIs

There are many different STIs and there are many signs that mean you may have caught one, but sometimes, there are no signs at all. When STIs do produce symptoms, they usually develop on the genital area. Your sexual contacts may also experience symptoms.

Generally, the symptoms of STIs can include:

  • -unusual discharge from the penis, vagina or anus
  • -pain during sex or urination
  • -sores, blisters, ulcers, warts or rashes in the genital area
  • -itchiness or irritation in the genital area
  • -persistent diarrhoea
  • -fever or flu-like symptoms
  • -abnormal or unusual vaginal bleeding, especially after having sex
  • -pain in the scrotum or testicles
  • -lumps and bumps on the genitals.

 

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Remember that many people who have an STI do not develop any symptoms and may not be aware they have an infection that can be passed on to their sexual partners, which is why check-ups are so important.

STIs are passed on during sex

The most common sexual activities that can spread an STI from one partner to another include:

        • -vaginal sex – the man’s penis in the woman’s vagina
        • -anal sex – the man’s penis in the partner’s anus (the partner can be either male or female)
        • -oral sex – the man’s penis in the partner’s mouth, or the partner’s mouth or tongue in the woman’s vagina
        • -oral-anal sex – one partner’s mouth or tongue on the other partner’s anus.

Diagnosis of STIs

The only way to find out if you have a sexually transmissible infection is to have a sexual health check-up. Doctors deal with sexual health problems on a daily basis, so don’t be embarrassed to ask for help.

Sexual health check-ups are easy to do. In most cases, it involves only a simple urine test. Some infections can be diagnosed on the day and treated at the time of your visit. Other results may take up to a week.

Testing for STIs

For people with no symptoms, testing for STIs depends on how sexually active you are and whether you use condoms consistently. It is recommended that you get tested:

  • -after any unprotected sexual contact with a new or casual sexual partner
  • -after any unprotected sex, if you know or suspect that your partner has had other sexual -partners
  • -after any unwanted or nonconsensual sexual contact
  • -after any unprotected sexual contact in countries where HIV and other STIs are common.
  • -if your partner tells you that they have been diagnosed with a sexually transmitted infection.

If you are a gay man or a man who has sex with other men, it is important to get regular check-ups for STIs, including HIV and syphilis – at least every year. You should have more frequent (three-monthly) check-ups if you have a number of sexual partners.

More than 30 different types of bacteria, viruses and parasites causes STI so it would be best to get tested if you have had unsafe sex. There’s a lot of people believe that they would know if they have an STI, however as previously stated, STI shows no symptoms at all and the only way you will know if you are carrying one is to get tested.

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Treatment and Prevention

Antibiotics can be used to treat bacterial infections, like the ones that cause gonorrhea, syphilis, or chancroid. Gonorrhea often occurs at the same time as chlamydia, so doctors usually prescribe antibiotics to treat both gonorrhea and chlamydia.

People with acute hepatitis B are usually treated only for symptoms.Most adults clear the virus on their own. However, for the few people that do not, treatment exists to reduce the risk of long-term liver damage.

There is no cure for HIV. Doctors prescribe different combinations of antiviral medications to slow down the progress of the disease. Treatments can vary from one person to the next to determine what combination works best for you. Doctors also treat secondary infections that result from a weakened immune system.

Don’t be shy about asking new sexual partners if they have STIs, or letting them know if you have one. To avoid spreading STIs, people who are sexually active and have multiple partners can be routinely screened – and rapidly treated – by a doctor.

How to Prevent Getting An STD:

  • -Avoid having unprotected sex. Always use either a male or female condom and learn how to use them correctly to best protect against STIs.
  • -Avoid using shared, non-sterile needles for drugs, body piercing, or tattoos.
  • -Visit your doctor regularly to check for STIs.
  • -Learn more about STIs. The more you know about STIs, the better you can protect yourself against them. Speak to your doctor or pharmacist and look for resources in your community.

Anyone can get STI anytime, so why not talk to your doctor now and know your status?  It’s a lot easier to get treatment for it if you become positive as soon as possible, than deal with it later which can lead to serious infections. Always be smart when it comes to your health.

If you have become infected with an STD/STI life is not over. Join our community for like minded people, and start feeling normal again! Join Meet Positives Today

 

Meet People With Herpes

The post Meet People With Herpes appeared first on Meet Positives.

Now that you know you have herpes, you might be thinking that you are out of the dating game. Well, this is not the case. It is understandable to get mad at people you think infected you or feeling depressed but this is the kind of attitude that will make your life more miserable. To begin with, herpes might not be curable but it is not a deadly STD. With proper management and treatment, you will live a normal life with reduced outbreaks. The good news is that people with herpes are dating and you will need a few tips to meet people with herpes who are looking for people like you.

Herpes will not affect the qualities that have always attracted people to you, unless of course you isolate yourself, get low self esteem and become depressed. No one wants to be with a sad person regardless of whether they have herpes or not. If you want to meet people with herpes and enjoy your life, the first step is changing your attitude towards your infection. When you accept your situation, you get a different perspective and this opens doors towards happiness and dating.

One of the most common ways you can meet people with herpes is through herpes dating sites. Technology has brought about a number of changes in how we do things and one of these changes is dating. The rise of online dating sites has been experienced in the past decade and a half and now there are different dating sites that target specific kinds of people. STD dating sites have now become common owing to the fact that there are millions of people living with STDs. These people would rather meet other positive singles than date uninfected people because of the rejection and awkwardness involved.

There are quite a number of dating sites but Meet Positives is one of the top STD dating sites where you can meet people with herpes. The site is easy to join and creating a profile will only take a few of your minutes. Within a short period, you will have an account and can start looking for potential partners and receiving messages. Any adult can use the site and the good thing is that the members control the information displayed on their profile. This is just to increase the security and privacy and to keep away people with unlawful intentions.

If you want to meet people with herpes, you can join an STD dating site such as Meetpositives.com. This site will have more than just a dating platform. You will have access to herpes forums and discussions where you can meet herpes singles and talk about different issues and how to cope with the infection. The information you get on these forums will be more than important in assisting you deal with your herpes infection and relationship matters. Meeting people with herpes is one way to feel comfortable since these people will understand you and will not be quick to judge you.

HSV Dating Sites

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Herpes dating might be quite a nightmare with infected individuals having to worry about how people will view them if they find out about their situation. The infection comes with a lot of stress as the infected will be in constant fear of rejection from those around them and their partners. The infection has led to a number of terminations of relationships; an uninfected person on the other hand will find it quite impossible to date a partner with herpes with fear of contracting the disease which has no cure. This remains the case but there are medications that can be used to treat and control the symptoms.

Singles infected looking to find partners will definitely have the allusion that they might be rejected whether they have been rejected before or not. A recent research done in the United States shows that 20% of the American population consisted of individuals infected with herpes with 70 percent not knowing they have the infection. This is good news to the infected; the statistics show that an infected individual can find a suitable partner with the disease. They cannot however go around asking everybody if they are infected. Modern technology has made it simple for people with HSV to date.

Meetpositives.com is one of the leading HSV dating sites that has created a perfect platform for dating where infected singles can interact and find potential partners. The website is free and has its members from all walks of life. Its free nature has enabled infected singles who cannot afford to pay dating sites that charge for their services get into the plan and consider finding partners. The members are very much welcoming and friendly; the site has a lot of infected individuals.

An infected person looking to find a partner will narrow down members that suit their preference and start conversations with them. The website has a user friendly interface that is easy to use. The site has leading icons that can enable a website amateur quickly familiarize with the features. Features such as messenger enable the members to send private messages to any member that they see possibly fit to date. Meet Positives and such other HSV dating sites have improvised privacy settings that the user can easily relate to that are meant to keep the website users safe from stalkers and bullies with unlawful intentions.

Infected users on Meet Positives are advised to conceal information during the start up conversations. This is due to the fact that not all dating site users are good and one cannot tell a person’s character as they will reveal what they want the other members to see and know. The HSV dating sites have eased the burden of having to open up to a partner of one’s condition and the stress that comes with having to think about their response or possible rejection. The members can also benefit from the organized forums as they will get to see and interact with other potential users and members of the HSV dating sites first hand.